A terapêutica antitrombótica: atual e em desenvolvimento
DOI:
https://doi.org/10.48750/acv.3Keywords:
Anticoalugação, Novos Anticoagulantes Orais, Terapêutica antiagregante, FarmacologiaAbstract
Thrombosis is one of the major causes of death worldwide. Continous increase in the knowledge about the pathophysiological changes associated with thrombosis led to the development of effective therapies (anti-platelet, anticoagulant and fibrinolytics) for the prevention and treatment of the thromboembolic disease.
However, better understanding of the underlying processes is still crucial for the development of more effective and safer antithrombotic drugs.
The aim of this review is summarize the current treatment, as well as the new agentes and to highlight their proven or possible role in Vascular Surgery.
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References
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mechanism of action and clinical development. Expert Rev Cardiovasc
Ther. 2009;7:1195---201.
31. Ferreiro JL, Ueno M, Tello-Montoliu A, et al. Effects of cangrelor
in coronary artery disease patients with and without diabetes
mellitus: An in vitro pharmacodynamic investigation. J Thromb
Thrombolysis. 2013;35:155---64.
32. Oestreich JH. Elinogrel, a reversible P2Y12 receptor antagonist
for the treatment of acute coronary syndrome and prevention
of secondary thrombotic events. Curr Opin Investig Drugs.
2010;11:340---8.
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therapy in emergency myocardial infarction treatment. Postepy
Kardiol Interwencyjnej. 2014;10:32---9, http://dx.doi.org/
10.5114/pwki.2014.41466.
34. Ferri N, Corsini A, Bellosta S. Pharmacology of the new P2Y12
receptor inhibitors: Insights on pharmacokinetic and pharmacodynamic
properties. Drugs. 2013;73:1681---709.
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pharmacodynamic and clinical profile of novel antiplatelet
drugs targeting vascular diseases. Br J Pharmacol.
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complex superficial femoral artery disease: A randomized trial.
Catheter Cardiovasc Interv. 2006;67:288---97.
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antiplatelet agent for secondary prevention in patients with a
history of atherosclerotic disease: Design and rationale for the
Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic
Ischemic Events (TRA 2 degrees P)-TIMI 50 trial.
Am Heart J. 2009;158:335---41, e3.
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and Outcomes With Vorapaxar in Patients With Peripheral
Artery Disease Results From the Trial to Assess the Effects of
Vorapaxar in Preventing Heart Attack and Stroke in Patients
With Atherosclerosis---Thrombolysis in Myocardial Infarction 50
(TRA2◦ P-TIMI 50). Circulation. 2016;133:997---1005.
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of cardiovascular events in diabetic patients. Vasc Health Risk
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prevention of cardiovascular events in patients with peripheral
artery disease: A meta-analysis of randomized trials.
JAMA. 2009;301:1909---19, http://dx.doi.org/10.1001/jama.
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combined inhibitor of thromboxane A2 synthase and receptor,
reduces 2year mortality in diabetics with peripheral arterial
disease: The DAVID study. Eur Heart J. 2004;25:1845---52.
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prevention of cardiovascular events in people with diabetes:
A position statement of the American Diabetes Association, a
scientific statement of the American Heart Association, and an
expert consensus document of the American College of Cardiology
Foundation. Circulation. 2010;121:2694---701, http://dx.
doi.org/10.1161/CIR.0b013e3181e3b133 pmid:20508178. Epub
2010/05/29.
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of cardiovascular events in patients without clinical
cardiovascular disease: A meta-analysis of randomized trials.
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j.ahj.2011.04.006 pmid:21742097, e2. Epub 2011/07/12.
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2. Bhatt DL, Topol EJ. Scientific and therapeutic advances in
antiplatelet therapy. Nat Rev Drug Discov. 2003;2:15---28,
http://dx.doi.org/10.1038/nrd985.
3. Garg VP, Halperin JL. Novel antiplatelet and anticoagulant
agents in the cardiac care unit. Cardiol Clin. 2013;31:533---44.
4. Moog S, Mangin P, Lenain N, et al. Platelet glycoprotein V binds
to collagen and participates in platelet adhesion and agreggation.
Blood. 2011;98:1038---46.
5. Gale AJ. Continuing education course #2: Current understanding
of hemostasis. Toxicol Pathol. 2011;39:273---80.
6. Antiplatelet Trialists’ Collaboration. Collaborative overview of
randomised trials of antiplatelet therapy–I: Prevention of death,
myocardial infarction, and stroke by prolonged antiplatelet therapy
in various categories of patients. BMJ. 1994;308:81---106.
7. Berger JS, Krantz MJ, Kittelson JM, et al. Aspirin for the prevention
of cardiovascular events in patients with peripheral
artery disease: A meta-analysis of randomized trials. JAMA.
2009;301:1909---19.
8. Halawani S, Brittenden J, Bachoo P, et al. Evaluation of Aspirin
Resistance in Peripheral Arterial Disease. J Thromb Haemost.
2005;S1:P1140.
9. Janzon L, Bergqvist D, Boberg J, et al. Prevention of myocardial
infarction and stroke in patients with intermittent claudication;
effects of ticlopidine. Results from STIMS, the Swedish
Ticlopidine Multicentre Study. J Intern Med. 1990;227:301---8.
10. Cadroy Y, Bossavy JP, Thalamas C, et al. Early potent antithrombotic
effect with combined aspirin and a loading dose of
clopidogrel on experimental arterial thrombogenesis in humans.
Circulation. 2000;101:2823---8.
11. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel
versus aspirin in patients at risk of ischaemic events
(CAPRIE). Lancet. 1996;348:1329---39.
12. Norgren L, Hiatt WR, Dormandy JA, et al. Inter-society consensus
for the management of peripheral arterial disease (TASC II).
J Vasc Surg. 2007;45 SupplS:S5---67.
13. Rooke TW, Hirsch AT, Misra S, et al. Focused update of the
Guideline for the Management of Patients With Peripheral
Artery Disease (Updating the 2005 Guideline): A Report of the
American College of Cardiology Foundation/American Heart
Association Task Force on Practice Guidelines. J Am Coll Cardiol.
2011;58:2020---45.
14. Tendera M, Aboyans V, Bartelink ML, et al. ESC Guidelines on the
diagnosis and treatment of peripheral artery diseases: Document
covering atherosclerotic disease of extracranial carotid
and vertebral, mesenteric, renal, upper and lower extremity
arteries: the Task Force on the Diagnosis and Treatment of
Peripheral Artery Diseases of the European Society of Cardiology
(ESC). Eur Heart J. 2011;32:2851---906.
15. Alonso-Coello P, Bellmunt S, McGorrian C, et al. Antithrombotic
therapy in peripheral artery disease: Antithrombotic Therapy
and Prevention of Thrombosis, 9th ed: American College
of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Chest. 2012;141 2Suppl:e669S---90S.
16. Bhatt Deepak L, Topol EJ, CHARISMA Executive Committee.
Clopidogrel added to aspirin versus aspirin alone in secondary
prevention and high-risk primary prevention: Rationale and
design of the Clopidogrel for High Atherothrombotic Risk and
Ischemic Stabilization, Management, and Avoidance (CHARISMA)
trial. Am Heart J. 2004;148:263---8.
17. Scheinert D, Schroder M, Ludwig J, et al. Stent-supported
recanalization of chronic iliac occlusions. Am J Med.
2001;110:708---15.
18. Mwipatayi BP, Thomas S, Wong J, et al. A comparison of covered
versus bare expandable stents for the treatment of aortoiliac
occlusive disease. J Vasc Surg. 2011;54:1561---70.
19. Sabeti S, Mlekusch W, Amighi J, et al. Primary patency of long-
-segment self-expanding nitinol stents in the femoropopliteal
arteries. J Endovasc Ther. 2005;12:6---12.
20. Laird JR, Katzen BT, Scheinert DT, et al. Nitinol stent implantation
versus balloon angioplasty for lesions in the superficial
femoral artery and proximal popliteal artery. Twelve-month
results from the RESILIENT randomized trial. Circ Cardiovasc
Interv. 2010;3:267---76.
21. Dake M, Ansel G, Jaff MR, et al. Paclitaxel-eluting stents show
superiority to balloon angioplasty and bare-metal stents in
femoropopliteal disease: Twelve-month Zilver PTX randomized
study results. Circ Cardiovasc Interv. 2011;4:495---504.
22. Werk M, Langner S, Reinkensmeier B, et al. Inhibition of restenosis
in femoropopliteal arteries: Paclitaxel-Coated Versus
Uncoated Balloon: Femoral Paclitaxel Randomized pilot trial.
Circulation. 2008;118:1358---65.
23. Micari A, Cioppa A, Vadalà G, et al. Clinical evaluation of
a paclitaxel-eluting balloon for treatment of femoropopliteal
arterial disease: 12-month results from a multicenter Italian
registry. JACC Cardiovasc Interv. 2012;5:331---8.
24. Eisenstein EL, Anstrom KJ, Kong DF, et al. Clopidogrel use and
long-term clinical outcomes after drug-eluting stent implantation.
JAMA. 2007;297:159---68.
25. Cocheri S. Antiplatelet drugs --- do we need new options?
With a reprpraisal of direct thromboxan inhibitors. Drugs.
2010;70:887---908.
26. Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel
in patients with acute coronary syndromes. N Engl Med.
2009;361:1045---57.
27. Patel MR, Becker RC, Wojdyla DM, et al. Cardiovascular events
in acute coronary syndrome patients with peripheral arterial
disease treated with ticagrelor compared with clopidogrel:
Data from the PLATO Trial. Eur J Prev Cardiol. 2015;22:
734---42.
28. Bonaca MP, Bhatt DL, Cohen M, et al. Long-term use of ticagrelor
in patients with prior myocardial infarction. N Engl J Med.
2015;372:1791---800.
29. Berger JS, Katona BG, Jones WS, et al. Design and rationale
for the effects of ticagrelor and clopidogrel in patients with
peripheral artery disease (EUCLID) Trial. Am Heart J. 2016.
30. Ferreiro JL, Ueno M, Angiolillo DJ. Cangrelor: A review on its
mechanism of action and clinical development. Expert Rev Cardiovasc
Ther. 2009;7:1195---201.
31. Ferreiro JL, Ueno M, Tello-Montoliu A, et al. Effects of cangrelor
in coronary artery disease patients with and without diabetes
mellitus: An in vitro pharmacodynamic investigation. J Thromb
Thrombolysis. 2013;35:155---64.
32. Oestreich JH. Elinogrel, a reversible P2Y12 receptor antagonist
for the treatment of acute coronary syndrome and prevention
of secondary thrombotic events. Curr Opin Investig Drugs.
2010;11:340---8.
33. Komosa A, Lesiak M, Siniawski A, et al. Significance of antiplatelet
therapy in emergency myocardial infarction treatment. Postepy
Kardiol Interwencyjnej. 2014;10:32---9, http://dx.doi.org/
10.5114/pwki.2014.41466.
34. Ferri N, Corsini A, Bellosta S. Pharmacology of the new P2Y12
receptor inhibitors: Insights on pharmacokinetic and pharmacodynamic
properties. Drugs. 2013;73:1681---709.
35. Siller-Matula JM, Krumphuber J, Bernd J. Pharmacokinetic,
pharmacodynamic and clinical profile of novel antiplatelet
drugs targeting vascular diseases. Br J Pharmacol.
2010;159:502---17.
36. Kalantzi KI, Tsoumani ME, Goudevenos IA, et al. Pharmacodynamic
properties of antiplatelet agents: Current knowledge and
future perspectives. Expert Rev Clin Pharmacol. 2012;5:319---36.
37. Stangl PA, Lewis S. Review of currently available GP IIb/IIIa inhibitors
and their role in peripheral vascular interventions. Semin
Intervent Radiol. 2010;27(No. 4). Thieme Medical Publishers.
38. Dörffler-Melly J, Mahler F, Do DD, et al. Adjunctive abciximab
improves patency and functional outcome in endovascular
treatment of femoropopliteal occlusions: Initial experience.
Radiology. 2005;237:1103---9.
39. Ansel GM, Silver MJ, Botti CF Jr, et al. Functional and clinical
outcomes of nitinol stenting with and without abciximab for
complex superficial femoral artery disease: A randomized trial.
Catheter Cardiovasc Interv. 2006;67:288---97.
40. Morrow DA, Scirica BM, Fox KA, et al. Evaluation of a novel
antiplatelet agent for secondary prevention in patients with a
history of atherosclerotic disease: Design and rationale for the
Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic
Ischemic Events (TRA 2 degrees P)-TIMI 50 trial.
Am Heart J. 2009;158:335---41, e3.
41. Bonaca MP, Gutierrez JA, Creager M, et al. Acute Limb Ischemia
and Outcomes With Vorapaxar in Patients With Peripheral
Artery Disease Results From the Trial to Assess the Effects of
Vorapaxar in Preventing Heart Attack and Stroke in Patients
With Atherosclerosis---Thrombolysis in Myocardial Infarction 50
(TRA2◦ P-TIMI 50). Circulation. 2016;133:997---1005.
42. (a) Celestini A, Violi F. A review of picotamide in the reduction
of cardiovascular events in diabetic patients. Vasc Health Risk
Manag. 2007;3:93---8;
(b) Berger JS, Krantz MJ, Kittelson JM, et al. Aspirin for the
prevention of cardiovascular events in patients with peripheral
artery disease: A meta-analysis of randomized trials.
JAMA. 2009;301:1909---19, http://dx.doi.org/10.1001/jama.
2009.623 pmid:19436018. Epub 2009/05/14.
43. Ferreiro JL, Angiolillo DJ. New directions in antiplatelet therapy.
Circ Cardiovasc Interv. 2012;5:433---45.
44. Neri Serneri GG, Coccheri S, Marubini E, et al. Picotamide, a
combined inhibitor of thromboxane A2 synthase and receptor,
reduces 2year mortality in diabetics with peripheral arterial
disease: The DAVID study. Eur Heart J. 2004;25:1845---52.
45. Pignone M, Alberts MJ, Colwell JA, et al. Aspirin for primary
prevention of cardiovascular events in people with diabetes:
A position statement of the American Diabetes Association, a
scientific statement of the American Heart Association, and an
expert consensus document of the American College of Cardiology
Foundation. Circulation. 2010;121:2694---701, http://dx.
doi.org/10.1161/CIR.0b013e3181e3b133 pmid:20508178. Epub
2010/05/29.
46. Berger JS, Lala A, Krantz MJ, et al. Aspirin for the prevention
of cardiovascular events in patients without clinical
cardiovascular disease: A meta-analysis of randomized trials.
Am Heart J. 2011;162:115---24, http://dx.doi.org/10.1016/
j.ahj.2011.04.006 pmid:21742097, e2. Epub 2011/07/12.
47. Katsanos K, Spiliopoulos S, Saha P, et al. Comparative efficacy
and safety of different antiplatelet agents for prevention
of major cardiovascular events and leg amputations in patients
with peripheral arterial disease: A systematic review and
network meta-analysis. PLoS One. 2015;10.8:e0135692.
48. Silvestre L, Ministro A, Evangelista A, et al. Novos anticoagulantes
orais no tromboembolismo venoso e fibrilhac¸ão auricular.
Ang Cir Vasc. 2012;8:06---11.
49. Eikelboom J, Weitz J. Update on Antithrombotic Therapy - New
Anticoagulants. Circulation. 2010;121:1523---32.
50. Mueck W, Stampfuss J, Kubitza D, et al. Clinical pharmacokinetic
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2016-11-22
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1.
Afonso A, Marques G, Gonçalves A, Barroso P, Gonzalez A, Rodrigues H, Ferreira MJ. A terapêutica antitrombótica: atual e em desenvolvimento. Angiol Cir Vasc [Internet]. 2016 Nov. 22 [cited 2024 Dec. 27];12(3):170-9. Available from: https://acvjournal.com/index.php/acv/article/view/3
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