NOVOS CONCEITOS SOBRE ADIPOSIDADE NA PATOLOGIA DA AORTA ABDOMINAL
DOI:
https://doi.org/10.48750/acv.70Palavras-chave:
Abdominal aortic aneurysm, peripheral arterial disease, visceral adipose tissue, periaortic adipose tissueResumo
O tecido adiposo perivascular tem tido cada vez mais reconhecimento como um importante produtor de fatores vasoativos e de citocinas que podem ter um efeito parácrino direto na vasculatura devido à sua inerente proximidade. A este respeito, a interação tecido adiposo perivascular-vaso pode ser identificada como um novo alvo terapêutico de doenças vasculares.
Contrariamente a outros depósitos adiposos específicos, cuja importância tem sido crescentemente divulgada, as propriedades do tecido adiposo periaórtico abdominal permanecem obscuras. As substâncias produzidas por este compartimento adiposo podem desempenhar um papel nas vias patológicas que ocorrem em doenças como o aneurisma da aorta abdominal e/ou a aterosclerose aórtica. Abordagens para esclarecer a sua importância são passos fundamentais na definição de estratégias terapêuticas inovadoras que enderecem a adventícia em vez da íntima danificada das artérias.
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Referências
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Perivascular adipose tissue control of insulin-induced vasoreactivity
in muscle is impaired in db/db mice. Diabetes. 2013;62:590-8.
4. Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK,
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Cardiovasc Diagn Ther. 2014;4:416-29.
5. Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P,
Tibblin G. Abdominal adipose tissue distribution, obesity, and risk
of cardiovascular disease and death: 13 year follow up of participants
in the study of men born in 1913. Br Med J (Clin Res Ed).
1984;288:1401-4.
6. Takagi H, Umemoto T. A meta-analysis of the association of
obesity with abdominal aortic aneurysm presence. Int Angiol.
2015;34:383-91.
7. Cronin O, Liu D, Bradshaw B, Iyer V, Buttner P, Cunningham M, et
al. Visceral adiposity is not associated with abdominal aortic
aneurysm presence and growth. Vasc Med. 2014;19:272-80.
8. Stackelberg O, Bjorck M, Sadr-Azodi O, Larsson SC, Orsini N, Wolk A.
Obesity and abdominal aortic aneurysm. Br J Surg. 2013;100:360-6.
9. De Rango P, Farchioni L, Fiorucci B, Lenti M. Diabetes and abdominal
aortic aneurysms. Eur J Vasc Endovasc Surg. 2014;47:243-61.
10. Lederle FA. The strange relationship between diabetes and abdominal
aortic aneurysm. Eur J Vasc Endovasc Surg. 2012;43:254-6.
11. Thanassoulis G, Massaro JM, Corsini E, Rogers I, Schlett CL, Meigs
JB, et al. Periaortic adipose tissue and aortic dimensions in the
Framingham Heart Study. J Am Heart Assoc. 2012;1:e000885.
12. Fox CS, Massaro JM, Schlett CL, Lehman SJ, Meigs JB, O'Donnell CJ,
et al. Periaortic fat deposition is associated with peripheral arterial
disease: the Framingham heart study. Circ Cardiovasc Imaging.
2010;3:515-9.
13. Planas A, Clara A, Pou JM, Vidal-Barraquer F, Gasol A, de Moner A,
et al. Relationship of obesity distribution and peripheral arterial
occlusive disease in elderly men. Int J Obes Relat Metab Disord.
2001;25:1068-70.
14. Vogt MT, Cauley JA, Kuller LH, Hulley SB. Prevalence and correlates
of lower extremity arterial disease in elderly women. Am J
Epidemiol. 1993;137:559-68.
15. Golledge J, Leicht A, Crowther RG, Clancy P, Spinks WL, Quigley
F. Association of obesity and metabolic syndrome with the
severity and outcome of intermittent claudication. J Vasc Surg.
2007;45:40-6.
16. Britton KA, Wang N, Palmisano J, Corsini E, Schlett CL, Hoffmann
U, et al. Thoracic periaortic and visceral adipose tissue and their
cross-sectional associations with measures of vascular function.
Obesity (Silver Spring). 2013;21:1496-503.
17. Spiroglou SG, Kostopoulos CG, Varakis JN, Papadaki HH. Adipokines
in periaortic and epicardial adipose tissue: differential
expression and relation to atherosclerosis. J Atheroscler Thromb.
2010;17:115-30.
18. Kranendonk ME, van Herwaarden JA, Stupkova T, de Jager W, Vink
A, Moll FL, et al. Inflammatory characteristics of distinct abdominal
adipose tissue depots relate differently to metabolic risk
factors for cardiovascular disease: distinct fat depots and vascular
risk factors. Atherosclerosis. 2015;239:419-27.
19. Folkesson M, Vorkapic E, Gulbins E, Japtok L, Kleuser B, Welander
M, et al. Inflammatory cells, ceramides, and expression of proteases
in perivascular adipose tissue adjacent to human abdominal
aortic aneurysms. J Vasc Surg. 2016;
-mass index and mortality in a prospective cohort of U.S. adults. N
Engl J Med. 1999;341:1097-105.
2. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity
with cardiovascular disease. Nature. 2006;444:875-80.
3. Meijer RI, Bakker W, Alta CL, Sipkema P, Yudkin JS, Viollet B, et al.
Perivascular adipose tissue control of insulin-induced vasoreactivity
in muscle is impaired in db/db mice. Diabetes. 2013;62:590-8.
4. Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK,
Wong DT. Epicardial adipose tissue: far more than a fat depot.
Cardiovasc Diagn Ther. 2014;4:416-29.
5. Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P,
Tibblin G. Abdominal adipose tissue distribution, obesity, and risk
of cardiovascular disease and death: 13 year follow up of participants
in the study of men born in 1913. Br Med J (Clin Res Ed).
1984;288:1401-4.
6. Takagi H, Umemoto T. A meta-analysis of the association of
obesity with abdominal aortic aneurysm presence. Int Angiol.
2015;34:383-91.
7. Cronin O, Liu D, Bradshaw B, Iyer V, Buttner P, Cunningham M, et
al. Visceral adiposity is not associated with abdominal aortic
aneurysm presence and growth. Vasc Med. 2014;19:272-80.
8. Stackelberg O, Bjorck M, Sadr-Azodi O, Larsson SC, Orsini N, Wolk A.
Obesity and abdominal aortic aneurysm. Br J Surg. 2013;100:360-6.
9. De Rango P, Farchioni L, Fiorucci B, Lenti M. Diabetes and abdominal
aortic aneurysms. Eur J Vasc Endovasc Surg. 2014;47:243-61.
10. Lederle FA. The strange relationship between diabetes and abdominal
aortic aneurysm. Eur J Vasc Endovasc Surg. 2012;43:254-6.
11. Thanassoulis G, Massaro JM, Corsini E, Rogers I, Schlett CL, Meigs
JB, et al. Periaortic adipose tissue and aortic dimensions in the
Framingham Heart Study. J Am Heart Assoc. 2012;1:e000885.
12. Fox CS, Massaro JM, Schlett CL, Lehman SJ, Meigs JB, O'Donnell CJ,
et al. Periaortic fat deposition is associated with peripheral arterial
disease: the Framingham heart study. Circ Cardiovasc Imaging.
2010;3:515-9.
13. Planas A, Clara A, Pou JM, Vidal-Barraquer F, Gasol A, de Moner A,
et al. Relationship of obesity distribution and peripheral arterial
occlusive disease in elderly men. Int J Obes Relat Metab Disord.
2001;25:1068-70.
14. Vogt MT, Cauley JA, Kuller LH, Hulley SB. Prevalence and correlates
of lower extremity arterial disease in elderly women. Am J
Epidemiol. 1993;137:559-68.
15. Golledge J, Leicht A, Crowther RG, Clancy P, Spinks WL, Quigley
F. Association of obesity and metabolic syndrome with the
severity and outcome of intermittent claudication. J Vasc Surg.
2007;45:40-6.
16. Britton KA, Wang N, Palmisano J, Corsini E, Schlett CL, Hoffmann
U, et al. Thoracic periaortic and visceral adipose tissue and their
cross-sectional associations with measures of vascular function.
Obesity (Silver Spring). 2013;21:1496-503.
17. Spiroglou SG, Kostopoulos CG, Varakis JN, Papadaki HH. Adipokines
in periaortic and epicardial adipose tissue: differential
expression and relation to atherosclerosis. J Atheroscler Thromb.
2010;17:115-30.
18. Kranendonk ME, van Herwaarden JA, Stupkova T, de Jager W, Vink
A, Moll FL, et al. Inflammatory characteristics of distinct abdominal
adipose tissue depots relate differently to metabolic risk
factors for cardiovascular disease: distinct fat depots and vascular
risk factors. Atherosclerosis. 2015;239:419-27.
19. Folkesson M, Vorkapic E, Gulbins E, Japtok L, Kleuser B, Welander
M, et al. Inflammatory cells, ceramides, and expression of proteases
in perivascular adipose tissue adjacent to human abdominal
aortic aneurysms. J Vasc Surg. 2016;
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Publicado
2018-06-07
Como Citar
1.
Dias-Neto M, Nunes F, Almeida G, Ramos JF, Teixeira JF, Sampaio S, Leite-Moreira A, Henriques-Coelho T. NOVOS CONCEITOS SOBRE ADIPOSIDADE NA PATOLOGIA DA AORTA ABDOMINAL. Angiol Cir Vasc [Internet]. 7 de Junho de 2018 [citado 24 de Novembro de 2024];14(2):133-8. Disponível em: https://acvjournal.com/index.php/acv/article/view/70
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