NEW CONCEPTS IN ADIPOSE TISSUE AND ABDOMINAL AORTIC PATHOLOGY
DOI:
https://doi.org/10.48750/acv.70Keywords:
Aneurisma da aorta abdominal, doença arterial periférica, tecido adiposo visceral, tecido adiposo periaórticoAbstract
Perivascular adipose tissue has been increasingly recognized as an important producer of vasoactive factors and cytokines that may have a direct paracrine effect on the vasculature due to the inherent proximity. In this regard, perivascular adipose tissue-vessel interaction might be identified as a novel therapeutic target of vascular diseases.
Conversely to other specific adipose depots, whose characteristics have been disclosed, proprieties of abdominal periaortic adipose tissue remain obscure. Substances produced by abdominal periaortic adipose tissue may play a role in the pathologic pathways occurring in abdominal aortic aneurism and/or aortic atherosclerosis. Approaches to address this topic are fundamental steps towards innovative therapeutic strategies that address adventitia instead of the damaged intima of peripheral vessels.
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Engl J Med. 1999;341:1097-105.
2. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity
with cardiovascular disease. Nature. 2006;444:875-80.
3. Meijer RI, Bakker W, Alta CL, Sipkema P, Yudkin JS, Viollet B, et al.
Perivascular adipose tissue control of insulin-induced vasoreactivity
in muscle is impaired in db/db mice. Diabetes. 2013;62:590-8.
4. Talman AH, Psaltis PJ, Cameron JD, Meredith IT, Seneviratne SK,
Wong DT. Epicardial adipose tissue: far more than a fat depot.
Cardiovasc Diagn Ther. 2014;4:416-29.
5. Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P,
Tibblin G. Abdominal adipose tissue distribution, obesity, and risk
of cardiovascular disease and death: 13 year follow up of participants
in the study of men born in 1913. Br Med J (Clin Res Ed).
1984;288:1401-4.
6. Takagi H, Umemoto T. A meta-analysis of the association of
obesity with abdominal aortic aneurysm presence. Int Angiol.
2015;34:383-91.
7. Cronin O, Liu D, Bradshaw B, Iyer V, Buttner P, Cunningham M, et
al. Visceral adiposity is not associated with abdominal aortic
aneurysm presence and growth. Vasc Med. 2014;19:272-80.
8. Stackelberg O, Bjorck M, Sadr-Azodi O, Larsson SC, Orsini N, Wolk A.
Obesity and abdominal aortic aneurysm. Br J Surg. 2013;100:360-6.
9. De Rango P, Farchioni L, Fiorucci B, Lenti M. Diabetes and abdominal
aortic aneurysms. Eur J Vasc Endovasc Surg. 2014;47:243-61.
10. Lederle FA. The strange relationship between diabetes and abdominal
aortic aneurysm. Eur J Vasc Endovasc Surg. 2012;43:254-6.
11. Thanassoulis G, Massaro JM, Corsini E, Rogers I, Schlett CL, Meigs
JB, et al. Periaortic adipose tissue and aortic dimensions in the
Framingham Heart Study. J Am Heart Assoc. 2012;1:e000885.
12. Fox CS, Massaro JM, Schlett CL, Lehman SJ, Meigs JB, O'Donnell CJ,
et al. Periaortic fat deposition is associated with peripheral arterial
disease: the Framingham heart study. Circ Cardiovasc Imaging.
2010;3:515-9.
13. Planas A, Clara A, Pou JM, Vidal-Barraquer F, Gasol A, de Moner A,
et al. Relationship of obesity distribution and peripheral arterial
occlusive disease in elderly men. Int J Obes Relat Metab Disord.
2001;25:1068-70.
14. Vogt MT, Cauley JA, Kuller LH, Hulley SB. Prevalence and correlates
of lower extremity arterial disease in elderly women. Am J
Epidemiol. 1993;137:559-68.
15. Golledge J, Leicht A, Crowther RG, Clancy P, Spinks WL, Quigley
F. Association of obesity and metabolic syndrome with the
severity and outcome of intermittent claudication. J Vasc Surg.
2007;45:40-6.
16. Britton KA, Wang N, Palmisano J, Corsini E, Schlett CL, Hoffmann
U, et al. Thoracic periaortic and visceral adipose tissue and their
cross-sectional associations with measures of vascular function.
Obesity (Silver Spring). 2013;21:1496-503.
17. Spiroglou SG, Kostopoulos CG, Varakis JN, Papadaki HH. Adipokines
in periaortic and epicardial adipose tissue: differential
expression and relation to atherosclerosis. J Atheroscler Thromb.
2010;17:115-30.
18. Kranendonk ME, van Herwaarden JA, Stupkova T, de Jager W, Vink
A, Moll FL, et al. Inflammatory characteristics of distinct abdominal
adipose tissue depots relate differently to metabolic risk
factors for cardiovascular disease: distinct fat depots and vascular
risk factors. Atherosclerosis. 2015;239:419-27.
19. Folkesson M, Vorkapic E, Gulbins E, Japtok L, Kleuser B, Welander
M, et al. Inflammatory cells, ceramides, and expression of proteases
in perivascular adipose tissue adjacent to human abdominal
aortic aneurysms. J Vasc Surg. 2016;
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Published
2018-06-07
How to Cite
1.
Dias-Neto M, Nunes F, Almeida G, Ramos JF, Teixeira JF, Sampaio S, Leite-Moreira A, Henriques-Coelho T. NEW CONCEPTS IN ADIPOSE TISSUE AND ABDOMINAL AORTIC PATHOLOGY. Angiol Cir Vasc [Internet]. 2018 Jun. 7 [cited 2024 Nov. 24];14(2):133-8. Available from: https://acvjournal.com/index.php/acv/article/view/70
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Review Article
