RISK OF DEATH AFTER PACLITAXEL EXPOSURE DURING FEMOROPOPLITEAL ARTERY ANGIOPLASTY – NARRATIVE REVIEW

Authors

  • Tiago F. Ribeiro Serviço de Angiologia e Cirurgia Vascular, Hospital de Santa Marta — Centro Hospitalar Universitário de Lisboa Central, Portugal
  • Rita Soares Ferreira Serviço de Angiologia e Cirurgia Vascular, Hospital de Santa Marta — Centro Hospitalar Universitário de Lisboa Central, Portugal
  • Joana Cardoso Serviço de Angiologia e Cirurgia Vascular, Hospital de Santa Marta — Centro Hospitalar Universitário de Lisboa Central, Portugal
  • Adriana Figueiredo Serviço de Angiologia e Cirurgia Vascular, Hospital de Santa Marta — Centro Hospitalar Universitário de Lisboa Central, Portugal
  • Helena Fidalgo Serviço de Angiologia e Cirurgia Vascular, Hospital de Santa Marta — Centro Hospitalar Universitário de Lisboa Central, Portugal
  • Frederico Bastos Gonçalves Serviço de Angiologia e Cirurgia Vascular, Hospital de Santa Marta — Centro Hospitalar Universitário de Lisboa Central, Portugal
  • Maria Emília Ferreira Serviço de Angiologia e Cirurgia Vascular, Hospital de Santa Marta — Centro Hospitalar Universitário de Lisboa Central, Portugal

DOI:

https://doi.org/10.48750/acv.436

Keywords:

Peripheral Artery Disease, Endovascular Therapy, Paclitaxel Coated Devices

Abstract

Paclitaxel molecule has been on the market since 1991 and is indicated for the treatment of multiple neoplasms. Since 2012 has been used in endovascular devices for the treatment of peripheral artery disease and have become a mainstay in the treatment of symptomatic femoro-popliteal lesions, in particular for preventing arterial restenosis. They have a proven benefit in patency and freedom-from re-intervention up to 5 years. A recent meta-analysis of RCT showed an increased late-mortality rate, however, real-life cohorts analyses presents contradictory results. RCT meta-analysis is comprised mainly by claudicants, and CLTI patients are underrepresented. Further studies are needed to clarify this matter, in particular with a higher percentage of CLTI presentation. For now, patients should be advised about risks and benefits of paclitaxel exposure and a shared decision-making process should be followed.

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Published

2022-03-02

How to Cite

1.
F. Ribeiro T, Ferreira RS, Cardoso J, Figueiredo A, Fidalgo H, Gonçalves FB, Ferreira ME. RISK OF DEATH AFTER PACLITAXEL EXPOSURE DURING FEMOROPOPLITEAL ARTERY ANGIOPLASTY – NARRATIVE REVIEW. Angiol Cir Vasc [Internet]. 2022 Mar. 2 [cited 2022 May 19];17(4):313-7. Available from: https://acvjournal.com/index.php/acv/article/view/436

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Section

Review Article