THE ROLE OF THE RED CELL DISTRIBUTION WIDTH IN CAROTID ARTERY DISEASE

  • Luis Duarte-Gamas Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Portugal
  • António Pereira-Neves Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Portugal; Department of Biomedicine – Unit of Anatomy, Faculdade de Medicina da Universidade do Porto, Portugal
  • Mariana Fragão-Marques Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Portugal; Department of Clinical Pathology, Centro Hospitalar Universitário de São João, Porto, Portugal; Cardiovascular R&D Unit, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
  • Isabel Vilaça Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal
  • João P. Rocha-Neves Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Portugal; Department of Biomedicine – Unit of Anatomy, Faculdade de Medicina da Universidade do Porto, Portugal
  • José Teixeira Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal
Keywords: Carotid artery disease, Erythrocyte size determination, Biomarkers

Abstract

Introduction: Carotid disease affects 3-4% of the general population. The association between systemic low-grade inflammation and atherosclerosis has led to the study of blood biomarkers, such as red blood cell distribution width – coefficient of variation (RDW-CV), and their role in the pathophysiology and prognosis of carotid artery disease. The aim of this study was to review the literature regarding the relevance of RDW-CV in carotid artery disease. 

Methods: A Medline search was performed in order to identify publications focused on the physiopathology of RDW-CV and its impact in patients with carotid artery disease.

Results: Increased RDW-CV was associated with increased carotid intima-media thickness (CIMT) in several studies. It was associated with plaque presence and progression. One study demonstrated an independent association between all-cause and cardiovascular-related mortality in patients with asymptomatic carotid artery stenosis and increased RDW-CV. 

Conclusion: RDW-CV is a widely available, easy to measure, and low-cost marker that seems to be associated with subclinical carotid atherosclerosis. However, further studies are needed in order to determine its clinical relevance in this setting.

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Published
2020-12-13
Section
Review Article