Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review

Authors

  • Celso Nunes Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal
  • Juliana Sousa Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal
  • Vânia Oliveira Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal
  • Eduardo Silva Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal https://orcid.org/0000-0002-5202-9070
  • Leonor Baldaia Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal https://orcid.org/0000-0001-9979-8646
  • Miguel Silva Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal https://orcid.org/0000-0002-6881-7514
  • Luis Orelhas Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal https://orcid.org/0000-0003-2597-7507
  • Manuel Fonseca Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, Portugal

DOI:

https://doi.org/10.48750/acv.552

Keywords:

Statin, Hemodialysis, peripheral arterial disease, patient outcomes

Abstract

INTRODUCTION: The use of statins in hemodialysis patients is a topic of ongoing research and debate. Patients with chronic kidney disease on hemodialysis constitute a large proportion of patients treated in the vascular surgery field. Clinical data of the protective statin effect on this group is scarce and conflicting results exist regarding cardiovascular, cerebrovascular and limb outcomes.
METHODS: We performed a thorough electronic search of the literature using PubMed and Embase databases to understand the relationship between statin effect and cardiovascular, limb outcomes and cerebrovascular outcomes. A narrative review was constructed, based on the obtained literature.
RESULTS: Although the use of statins in hemodialysis patients may provide cardiovascular benefits, the optimal dosage and safety profile of these medications in this population remain uncertain. A carefully evaluation of the risks and benefits of statins should be made based on each patient's specific requirements and circumstances.
CONCLUSION: The role of statins for patients with peripheral arterial disease who are on hemodialysis remains unclear. Further analyses should focus on this subgroup of dialysis patients, who are becoming more prevalent on the vascular surgery departments, allowing for an optimized treatment with better patient outcomes.

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References

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Published

2024-03-03

How to Cite

1.
Nunes C, Sousa J, Oliveira V, Silva E, Baldaia L, Silva M, Orelhas L, Fonseca M. Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review. Angiol Cir Vasc [Internet]. 2024 Mar. 3 [cited 2024 Apr. 12];19(4):218-20. Available from: https://acvjournal.com/index.php/acv/article/view/552

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Section

Review Article